本帖意欲招募有志之士一起翻译Schreiber 的宏洪巨著Chemical Biology: From Small Molecules to Systems Biology and Drug Design(3-Volume Set)(化学生物学三卷集:从小分子到系统生物学和药物设计),以吸引更多的人加入到化学生物学的研究队伍中,为祖国的化学生物学科研事业略尽绵薄之力。
化学生物学(Chemical biology)是哈佛大学的斯图亚特·L·施莱伯等人所提倡,利用分子生物学的手法,搭配有机化学的方式,探讨细胞内核酸或是蛋白质等生物体内分子的功能或是反应。——Wikipedia
化学生物学历经近30年数以千计的化学、生物学和医学科研工作者的不懈耕耘已经成为化学和生物学界最活跃的领域之一,每年有数千篇paper发表。各大学术机构也都推出了化学生物学的专业性期刊,如ACS的ACS Chemical Biology,NPG的Nature Chemical Biology, Cell Press的Chemistry and Biology等。相比较而言,化学生物学的专业性书籍就很稀少了,特别是中文版的化学生物学书籍更是凤毛麟角。通常大家能在图书馆里见到的只有马林、古练全编的《化学生物学导论》(2007年化学工业出版社)和Waldmann编著、方唯硕等译的《化学生物学实验教程》(2006年化学工业出版社)两本。对于有志于从事和从事化学生物学研究的本科生和研究生而言,这两本书籍很难满足需要也未能体现化学生物学的庞大体系和日新月异的研究成果,所以大家不得不转向于艰深昂贵的英文书籍。Chemical Biology: From Small Molecules to Systems Biology and Drug Design(3-Volume Set)这本Handbook式的巨著相信几乎每一个化学生物学科研人都或多或少的读过其中的章节。这本由化学生物学创始人之一的Schreiber主编的Textbook很厚(1280页)、很贵($1096.41),但也很全面、很深刻,这样的书籍理应被引入中国出版中文版。某虽不才,但甘为牛马,召集国内才俊、有识之士一起完成这本宏著的翻译,推动中文译本的问世。
要求:
1. 从事化学、生物学等相关领域研究,熟悉化学生物学基础知识,精通中英文
2. 研究生高年级学生、博后、讲师、助研等,更欢迎教授、研究员的加入
3. 熟练掌握Word,会用ChemDraw、Photoshop、CorelDraw等软件
4. 有强烈的责任感和团队协作意识,在未来一年内有充足业余时间
5. 有书籍翻译和出版经验者优先
由于本书有3卷19章,所以打算招募大约20位翻译合作者,同时需要2-5名熟练掌握Photoshop、CorelDraw等图片处理工具的合作者完成书中插图和封面的制作工作,特别期望有出版工作经验的专业人士能加入我们,让我们大家一起将Chemical Biology: From Small Molecules to Systems Biology and Drug Design(3-Volume Set)带入中文界,让更多的同道之士能从中获益。
如果您有意愿加入这项计划,请Email联系我;如果您对这项计划有任何建议或意见,也请发Email给我。热切盼望着能见到大家对这项计划的支持和参与!
本人Email:qqzhang1986@outlook.com
Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Volume 1-3
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KgaA
Editor(s): Stuart L. Schreiber, Tarun M. Kapoor, Günther Wess
Published Online: 21 APR 2008
Print ISBN: 9783527311507
Online ISBN: 9783527619375
DOI: 10.1002/9783527619375
About this Book
Product Information
Edited by the world leaders in this emerging field, this three-volume handbook is designed to become the landmark reference on this exciting new branch of chemistry and biology. Following an introductory section, the authors discuss the use of small molecules to explore biology, discovering small molecule probes for biological mechanisms and expanding the scope of chemical synthesis. Further sections cover chemical informatics, drug discovery and systems biology, and the whole work is rounded off by the outlook and perspectives for this field. No academic institution or pharmaceutical company can possibly miss out on this highly authoritative work.
Table of contents
Frontmatter (pages i–xxv)
Part I: Chemistry and Biology — Historical and Philosophical Aspects - Introduction
Chapter 1
Chemistry and Biology — Historical and Philosophical Aspects (pages 3–67)
Gerhard Quinkert, Holger Wallmeier, Norbert Windhab and Dietmar Reichert
Part II: Using Small Molecules to Explore Biology - Using Natural Products to Unravel Biological Mechanisms
Chapter 2
Using Small Molecules to Unravel Biological Mechanisms (pages 71–94)
Michael A. Lampson and Tarun M. Kapoor
Chapter 2
Using Natural Products to Unravel Cell Biology (pages 95–114)
Jonathan D. Gough and Craig M. Crews
Part II: Using Small Molecules to Explore Biology - Engineering Control Over Protein Function Using Chemistry
Chapter 3
Revealing Biological Specificity by Engineering Protein-Ligand Interactions (pages 115–139)
Matthew D. Simon and Kevan M. Shokat
Chapter 3
Controlling Protein Function by Caged Compounds (pages 140–173)
Andrea Giordano, Sirus Zarbakhsh and Carsten Schultz
Chapter 3
Engineering Control Over Protein Function; Transcription Control by Small Molecules (pages 174–197)
John T. Koh
Part II: Using Small Molecules to Explore Biology - Controlling Protein-Protein Interactions
Chapter 4
Chemical Complementation: Bringing the Power of Genetics to Chemistry (pages 199–226)
Pamela Peralta-Yahya and Virginia W. Cornish
Chapter 4
Controlling Protein–Protein Interactions Using Chemical Inducers and Disrupters of Dimerization (pages 227–249)
Tim Clackson
Chapter 4
Protein Secondary Structure Mimetics as Modulators of Protein–Protein and Protein-Ligand Interactions (pages 250–269)
Hang Yin and Andrew D. Hamilton
Part II: Using Small Molecules to Explore Biology - Expanding the Genetic Code
Chapter 5
Synthetic Expansion of the Central Dogma (pages 271–295)
Masahiko Sisido
Part III: Discovering Small Molecule Probes for Biological Mechanisms
Chapter 6
Forward Chemical Genetics (pages 299–354)
Stephen J. Haggarty and Stuart L. Schreiber
Part III: Discovering Small Molecule Probes for Biological Mechanisms - Reverse Chemical Genetics Revisited
Chapter 7
Reverse Chemical Genetics – An Important Strategy for the Study of Protein Function in Chemical Biology and Drug Discovery (pages 355–384)
Rolf Breinbauer, Alexander Hillisch and Herbert Waldmann
Chapter 7
Chemical Biology and Enzymology: Protein Phosphorylation as a Case Study (pages 385–402)
Philip A. Cole
Chapter 7
Chemical Strategies for Activity-based Proteomics (pages 403–426)
Nadim Jessani and Benjamin F. Cravatt
Part III: Discovering Small Molecule Probes for Biological Mechanisms - Tags and Probes for Chemical Biology
Chapter 8
The Biarsenical-tetracysteine Protein Tag: Chemistry and Biological Applications (pages 427–457)
Stephen R. Adams
Chapter 8
Chemical Approaches to Exploit Fusion Proteins for Functional Studies (pages 458–479)
Anke Arnold, India Sielaff, Nils Johnsson and Kai Johnsson
Part IV: Expanding the Scope of Chemical Synthesis - Diversity-Oriented Synthesis
Chapter 9
Diversity-oriented Synthesis (pages 483–518)
Derek S. Tan
Part IV: Expanding the Scope of Chemical Synthesis - Diversity-oriented Synthesis
Chapter 9
Combinatorial Biosynthesis of Polyketides and Nonribosomal Peptides (pages 519–536)
Nathan A. Schnarr and Chaitan Khosla
Part IV: Expanding the Scope of Chemical Synthesis - Synthesis of Large Biological Molecules
Chapter 10
Expressed Protein Ligation (pages 537–566)
Matthew R. Pratt and Tom W. Muir
Chapter 10
Chemical Synthesis of Proteins and Large Bioconjugates (pages 567–592)
Philip Dawson
Chapter 10
New Methods for Protein Bioconjugation (pages 593–634)
Matthew B. Francis
Part IV: Expanding the Scope of Chemical Synthesis - Advances in Sugar Chemistry
Chapter 11
The Search for Chemical Probes to Illuminate Carbohydrate Function (pages 635–667)
Laura L. Kiessling and Erin E. Carlson
Chapter 11
Chemical Glycomics as Basis for Drug Discovery (pages 668–691)
Daniel B. Werz and Peter H. Seeberger
Part IV: Expanding the Scope of Chemical Synthesis
Chapter 12
The Bicyclic Depsipeptide Family of Histone Deacetylase Inhibitors (pages 693–720)
Paul A. Townsend, Simon J. Crabb, Sean M. Davidson, Peter W. M. Johnson, Graham Packham and Arasu Ganesan
Part V: Chemical Informatics - Chemical Informatics
Chapter 13
Chemical Informatics (pages 723–759)
Paul A. Clemons
Chapter 13
WOMBAT and WOMBAT-PK: Bioactivity Databases for Lead and Drug Discovery (pages 760–786)
Marius Olah, Ramona Rad, Liliana Ostopovici, Alina Bora, Nicoleta Hadaruga, Dan Hadaruga, Ramona Moldovan, Adriana Fulias, Maria Mractc and Tudor I. Oprea
Part VI: Drug Discovery - Chemical Biology and Drug Discovery
Chapter 14
Managerial Challenges in Implementing Chemical Biology Platforms (pages 789–803)
Frank L. Douglas
Chapter 14
The Molecular Basis of Predicting Druggability (pages 804–823)
Bissau Al-Lazikani, Anna Gaulton, Gaia Paolini, Jerry Lanfear, John Overington and Andrew Hopkins
Part VI: Drug Discovery - Target Families
Chapter 15
The Target Family Approach (pages 825–851)
Hans Peter Nestler
Chapter 15
Chemical Biology of Kinases Studied by NMR Spectroscopy (pages 852–890)
Marco Betz, Martin Vogtherr, Ulrich Schieborr, Bettina Elshorst, Susanne Grimme, Barbara Pescatore, Thomas Langer, Krishna Saxena and Harald Schwalbe
Chapter 15
The Nuclear Receptor Superfamily and Drug Discovery (pages 891–932)
John T. Moore, Jon L. Collins and Kenneth H. Pearce
Chapter 15
The GPCR — 7TM Receptor Target Family (pages 933–978)
Edgar Jacoby, Rochdi Bouhelal, Marc Gerspacher and Klaus Seuwen
Chapter 15
Drugs Targeting Protein–Protein Interactions (pages 979–1002)
Patrick Chène
Part VI: Drug Discovery
Chapter 16
Prediction of ADMET Properties (pages 1003–1042)
Ulf Norinder and Christel A. S. Bergström
Part VII: Systems Biology - Computational Methods and Modeling
Chapter 17
Systems Biology of the JAK-STAT Signaling Pathway (pages 1045–1060)
Jens Timmer, Markus Kollmann and Ursula Klingmüller
Chapter 17
Modeling Intracellular Signal Transduction Processes (pages 1061–1081)
Jason M. Haugh and Michael C. Weiger
Part VII: Systems Biology - Genome and Proteome Studies
Chapter 18
Genome-wide Gene Expression Analysis: Practical Considerations and Application to the Analysis of T-cell Subsets in Inflammatory Diseases (pages 1083–1117)
Lars Rogge and Elisabetta Bianchi
Chapter 18
Scanning the Proteome for Targets of Organic Small Molecules Using Bifunctional Receptor Ligands (pages 1118–1139)
Nikolai Kley
Part VIII: Outlook
Chapter 19
Chemical Biology – An Outlook (pages 1143–1150)
Günther Wess
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Index (pages 1151–1205)
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