URL: http://www.aw-bc.com/mathews/ch19/squalene.htm

Squalene

Squalene is an intermediate in cholesterol and steroid biosynthesis. It is f
ormed from presqualene pyrophosphate (Figure 19.21) in the walls of the endo
plasmic reticulum using electrons from NADPH. In the reaction, the pyrophosp
hate is removed from the molecule.
Subsequently, squalene is cyclized to lanosterol, which is subsequently conv
erted to cholesterol (Figure 19.22).
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