A postdoctoral position will be available in Professor Lei Li’s group at Department of Chemistry & Chemical Biology, Indiana University-Purdue University Indianapolis. The projected starting date is August 2015; this date may be postponed for a few months if needed. The major focus of the Li laboratory is to use chemical biology means to understand the reactivity of nucleotide damages. Research projects include: (1) to elucidate the formation and repair of a thymine photo-dimer, 5-thyminyl-5,6-dihydrothymine, i.e. the spore photoproduct (SP), and (2) to understand the stability of DNA lesions such as 5,6-dihydro-2?-deoxyuridine (dHdU) and 5,6-dihydroxy-5,6-dihydrothymine (thymine glycol). Further information about the research in the Li group can be found at
http://chem.iupui.edu/~lilei/. The applicant should have a PhD degree in organic chemistry, possess strong synthetic skills and is interested in applying his/her skills to understand nucleic acids chemistry and biochemistry. Please send a brief description (1-2 pages) of past research, CV and 3 reference letters via email to lilei@iupui.edu.
[b]Selected publications from the Li group[/b]:
o Jian, Y.; Lin, G.; Chomicz, L.; & Li, L.* “Reactivity of Damaged Pyrimidines: Formation of a Schiff base intermediate at the glycosidic bond of saturated dihydrouridine”, J. Am. Chem. Soc. 2015, 3318-3329.
o Lin, G.; Jian, Y.; Dria, K. J.; Long, E. C.; & Li, L.* “Reactivity of Damaged Pyrimidines: DNA Cleavage via Hemiaminal Formation at the C4 Positions of the Saturated Thymine of Spore Photoproduct and Dihydrouridine”, J. Am. Chem. Soc., 2014, 136, 12938-12946.
o Lin, G. & Li, L.* “Oxidation and reduction of the 5-(2′-deoxyuridinyl)methyl radical”, Angew. Chem. Int. Ed., 2013, 5594–5598.
o Yang, L.; Lin, G.; Liu, D.; Dria, K. J.; Telser, J.; & Li, L.*“Probing the Reaction Mechanism of Spore Photoproduct Lyase (SPL) via Diastereoselectively Labeled Dinucleotide SP TpT Substrates” J. Am. Chem. Soc., 2011, 10434-47.
o Lin, G. & Li, L.* “Revealing the spore photoproduct (SP) formation via isotope labeling” Angew. Chem. Int. Ed., 2010, 9926-9929. (selected as a hot paper by Editor’s choice)
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